The human choline acetyltransferase gene encodes two proteins.

  title={The human choline acetyltransferase gene encodes two proteins.},
  author={D D Grosman and Matthew V Lorenzi and A C Trinidad and Wayne L Strauss},
  journal={Journal of neurochemistry},
  volume={65 2},
Both 2,500- and 6,000-nucleotide (nt) mRNAs are generated by alternative splicing of the primary transcript from the human gene for choline acetyltransferase (ChAT), the 68-kDa enzyme that synthesizes acetylcholine. In vitro translation of cRNA derived from a clone of the 2,500-nt mRNA produced a protein with ChAT activity demonstrating that this transcript encodes the human ChAT enzyme. An antibody directed against a unique amino acid sequence predicted from the 6,000-nt ChAT gene transcript… CONTINUE READING


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