The human burn wound as a primary source of interleukin-1 activity.

  title={The human burn wound as a primary source of interleukin-1 activity.},
  author={Thomas S Kupper and Edwin A. Deitch and Christopher C. Baker and Wai Chong Wong},
  volume={100 2},
It has been suggested that interleukin 1 (IL-1) may be elevated systemically after major burn injury. Several metabolic changes commonly observed in patients with burns can be attributed in part to elevated IL-1 production; these include temperature elevation, skeletal muscle proteolysis, and alterations in the production of certain serum proteins by the hepatocyte (e.g., albumin and acute phase reactants). In this article we describe a likely source of this elevated IL-1 activity: the burn… CONTINUE READING

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