The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins.

@article{Yamazaki2014TheHB,
  title={The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins.},
  author={Toyomi Yamazaki and Miki Sagisaka and Riko Ikeda and Toshiyuki Nakamura and Noriko Matsuda and Takeshi Ishii and Tsutomu Nakayama and Tatsuo Watanabe},
  journal={Bioscience, biotechnology, and biochemistry},
  year={2014},
  volume={78 10},
  pages={1753-6}
}
We purified several hundred mgs of four major theaflavins (theaflavin, theaflavin-3-O-gallate, theaflavin-3'-O-gallate, and theaflavin-3,3'-O-digallate). Among the 25 hTAS2Rs expressed in HEK293T cells, hTAS2R39 and hTAS2R14 were activated by theaflavins. Both hTAS2R39 and hTAS2R14 responded to theaflavin-3'-O-gallate. In addition, hTAS2R39 was activated by… CONTINUE READING