The human beta-interferon gene enhancer is under negative control.

@article{Goodbourn1986TheHB,
  title={The human beta-interferon gene enhancer is under negative control.},
  author={S. E. Y. Goodbourn and Harold J. Burstein and Tom Maniatis},
  journal={Cell},
  year={1986},
  volume={45 4},
  pages={601-10}
}
The human beta-interferon gene is regulated by an inducible enhancer element. Analysis of the effect of deletions within this element on beta-interferon transcription indicates that this enhancer is under negative control. Deletion of sequences from the 3' end of the enhancer leads to a dramatic increase in the basal level of beta-interferon mRNA and a decrease in the induction ratio. The remaining 5' region of the enhancer can act as a strong constitutive transcription element, and it shares… CONTINUE READING