The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells.

@article{Willment2005TheHB,
  title={The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells.},
  author={Janet A Willment and Andrew S. J. Marshall and Delyth M. Reid and David M. L. Williams and Simon Y. C. Wong and Siamon Gordon and Gordon D Brown},
  journal={European journal of immunology},
  year={2005},
  volume={35 5},
  pages={1539-47}
}
We identified the C-type-lectin-like receptor, Dectin-1, as the major receptor for fungal beta-glucans on murine macrophages and have demonstrated that it plays a significant role in the cellular response to these carbohydrates. Using two novel, isoform-specific mAb, we show here that human Dectin-1, the beta-glucan receptor (betaGR), is widely expressed and present on all monocyte populations as well as macrophages, DC, neutrophils and eosinophils. This receptor is also expressed on B cells… CONTINUE READING

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