The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.

@article{Yen1996TheHA,
  title={The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.},
  author={Pauline H. Yen and Ning Ning Chai and Eduardo C. Salido},
  journal={Human molecular genetics},
  year={1996},
  volume={5 12},
  pages={2013-7}
}
The DAZ (Deleted in AZoospermia) and DAZLA (DAZ-like autosomal) genes may be determinants of male infertility. The DAZ gene on the long arm of the human Y chromosome is a strong candidate for the 'azoospermia factor' (AZF). Its role in spermatogenesis is supported by its exclusive expression in testis, its deletion in a high percentage of males with azoospermia or severe oligospermia, and its homology with a Drosophila male infertility gene boule. No DAZ homologous sequences have been found on… CONTINUE READING