The human apolipoprotein E gene is negatively regulated in human liver HepG2 cells by the transcription factor BEF-1.

@article{Berg1995TheHA,
  title={The human apolipoprotein E gene is negatively regulated in human liver HepG2 cells by the transcription factor BEF-1.},
  author={David T. Berg and David S. Calnek and Brian William Grinnell},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 26},
  pages={15447-50}
}
Apolipoprotein E (apoE) is a major constituent of plasma lipoprotein that functions in lipid transport and redistribution (reverse cholesterol transport) and probably plays an important role in inhibiting the development and/or progression of atherosclerosis. While cis-acting regions involved in basal and tissue-specific control of the apoE gene have been identified by promoter mapping studies, much less is known about factors that regulate the gene. In this study, we demonstrate that the… CONTINUE READING

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