The human antibody repertoire specific for rabies virus glycoprotein as selected from immune libraries.

@article{Kramer2005TheHA,
  title={The human antibody repertoire specific for rabies virus glycoprotein as selected from immune libraries.},
  author={Robert Arjen Kramer and Wilfred E. Marissen and Jaap Goudsmit and Therese J. Visser and Marieke Clijsters-van der Horst and Arjen Q. Bakker and Maureen de Jong and Mandy A C Jongeneelen and Sandra Thijsse and Harold H.J. Backus and Amy B. Rice and William C. Weldon and Charles E. Rupprecht and Bernhard Dietzschold and Alexander B H Bakker and John de Kruif},
  journal={European journal of immunology},
  year={2005},
  volume={35 7},
  pages={
          2131-45
        }
}
Antibody phage display technology was used to identify human monoclonal antibodies that neutralize rabies virus (RV). A phage repertoire was constructed using antibody genes harvested from the blood of vaccinated donors. Selections using this repertoire and three different antigen formats of the RV glycoprotein (gp) resulted in the identification of 147 unique antibody fragments specific for the RV gp. Analysis of the DNA sequences of these antibodies demonstrated a large variation in the heavy… CONTINUE READING
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