The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases

@article{Chards2002TheHA,
  title={The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases},
  author={Thierry Chard{\`e}s and Nicolas Chapal and Damien Bresson and Cédric Bès and V{\'e}ronique Giudicelli and Marie-Paule Lefranc and Sylvie Péraldi-Roux},
  journal={Immunogenetics},
  year={2002},
  volume={54},
  pages={141-157}
}
Abstract. Human anti-thyroid peroxidase (TPO) autoantibodies (aAb) are generated during autoimmune thyroid diseases (AITD). Within recent years, increasing knowledge of the TPO-specific aAb repertoire, gained mainly by the use of combinatorial library methodology, has led to the cloning and sequencing of around 180 human anti-TPO aAb. Analysis of the immunoglobulin (Ig) variable (V) genes encoding the TPO aAb in the ImMunoGeneTics database (IMGT) (http://imgt.cines.fr) reveals major features of… Expand
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