The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases

@article{Chards2002TheHA,
  title={The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases},
  author={Thierry Chard{\`e}s and Nicolas Chapal and Damien Bresson and Cédric Bès and V{\'e}ronique Giudicelli and Marie-Paule Lefranc and Sylvie Péraldi-Roux},
  journal={Immunogenetics},
  year={2002},
  volume={54},
  pages={141-157}
}
Abstract. Human anti-thyroid peroxidase (TPO) autoantibodies (aAb) are generated during autoimmune thyroid diseases (AITD). Within recent years, increasing knowledge of the TPO-specific aAb repertoire, gained mainly by the use of combinatorial library methodology, has led to the cloning and sequencing of around 180 human anti-TPO aAb. Analysis of the immunoglobulin (Ig) variable (V) genes encoding the TPO aAb in the ImMunoGeneTics database (IMGT) (http://imgt.cines.fr) reveals major features of… 

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References

SHOWING 1-10 OF 79 REFERENCES

Analysis of immunoglobulin G kappa antithyroid peroxidase antibodies from different tissues in Hashimoto's thyroiditis.

TLDR
Although there is no unique Ab gene usage, there is the recurrent presence of certain variable regions in the high affinity TPO Ab response, similar to that in previously published TPO-reactive Fabs.

Recognition by recombinant autoimmune thyroid disease-derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase.

To characterize the nature of thyroid peroxidase (TPO) autoantibodies present in the sera of patients with autoimmune thyroid disease, we cloned three IgG1/kappa Fab fragments which bind 125I-TPO.

Autoimmune Response to the Thyroid in Humans: Thyroid Peroxidase-The Common Autoantigenic Denominator

Autoimmunity to thyroid peroxidase (TPO), manifest as high affinity IgG class auto-antibodies, is the common denominator of human thyroid autoimmunity, encompassing patients with overt hyper-or

Isolation and characterization of a monoclonal human thyroidperoxidase autoantibody of lambda light chain type

Somatic hypermutation in autoimmune thyroid disease.

Autoimmune thyroid disease is one of the most common autoimmune diseases. There is typically patient antibody (Ab) reactivity to one or more of the antigens thyroglobulin (Tg), thyroid peroxidase

Human monoclonal autoantibodies to B-cell epitopes outside the thyroid peroxidase autoantibody immunodominant region.

TLDR
The first insight into the immunoglobulin genes, affinities and epitopes of human monoclonal autoantibodies that bind outside the TPO-immunodominant region is provided.

Cloning and analysis of IgG kappa and IgG lambda anti-thyroglobulin autoantibodies from a patient with Hashimoto's thyroiditis: evidence for in vivo antigen-driven repertoire selection.

TLDR
19 high affinity, human Tg-specific Fab are isolated and it is shown that the relative affinity of the Fab is directly related to the pattern of somatic hypermutation.

Recombinant thyroid peroxidase-specific autoantibodies. I. How diverse is the pool of heavy and light chains in immunoglobulin gene libraries constructed from thyroid tissue-infiltrating plasma cells.

TLDR
The present data indicate that the restricted number of H chain genes used by TPO-specific autoantibodies cannot be ascribed to limited H chain gene diversity in the parent library; and L chains from combinatorial libraries cannot simply be regarded as plastic, or promiscuous, partners for high affinity antigen binding by a particular H chain.

Rarity of autoantibodies to a major autoantigen, thyroid peroxidase, that interact with denatured antigen or with epitopes outside the immunodominant region

TLDR
The findings demonstrate the bias of the human B cell repertoire towards recognition of an immunodominant region on the conformationally intact form of a major thyroid autoantigen.

Somatic hypermutation in antoimmune thyroid disease

TLDR
The Ab response in thyroid autoimmunity remains one of the best characterised of human autoimmune diseases.
...