The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases.

@article{Eckelman2006TheHA,
  title={The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases.},
  author={Brendan P Eckelman and Guy Salvesen},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 6},
  pages={3254-60}
}
cIAPs (cellular inhibitor of apoptosis proteins) 1 and 2 are able to regulate apoptosis when ectopically expressed in recipient cells and probably also in vivo. Previous work suggested that this is at least partially due to direct caspase inhibition, mediated by two of the three baculovirus IAP repeat (BIR) domains that are contained in these proteins. In support of this we show that the BIR domains 2 and 3 of the two cIAPs are able to bind caspases-7 and -9. However, we demonstrate that… CONTINUE READING
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