The human angiotensin AT(1) receptor supports G protein-independent extracellular signal-regulated kinase 1/2 activation and cellular proliferation.

@article{Hansen2008TheHA,
  title={The human angiotensin AT(1) receptor supports G protein-independent extracellular signal-regulated kinase 1/2 activation and cellular proliferation.},
  author={Jakob Lerche Hansen and Mark Aplin and Jonas Tind Hansen and Gitte Christensen and Marie Mi Bonde and Mikael Schneider and Stig Hauns\o and Hans H. Schiffer and Ethan S. Burstein and David M. Weiner and S\oren Paludan Sheikh},
  journal={European journal of pharmacology},
  year={2008},
  volume={590 1-3},
  pages={255-63}
}
The angiotensin AT(1) receptor is a key regulator of blood pressure and body fluid homeostasis, and it plays a key role in the pathophysiology of several cardiovascular diseases such as hypertension, cardiac hypertrophy, congestive heart failure, and arrhythmia. The importance of human angiotensin AT(1) receptor signalling is illustrated by the common use of angiotensin AT(1) receptor-inverse agonists in clinical practice. It is well established that rodent orthologues of the angiotensin AT(1… CONTINUE READING
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