The human androgen receptor X-chromosome inactivation assay for clonality diagnostics of natural killer cell proliferations.

@article{Boudewijns2007TheHA,
  title={The human androgen receptor X-chromosome inactivation assay for clonality diagnostics of natural killer cell proliferations.},
  author={Micha{\"e}l Boudewijns and Jacques JM van Dongen and Anton W. Langerak},
  journal={The Journal of molecular diagnostics : JMD},
  year={2007},
  volume={9 3},
  pages={337-44}
}
Clonality is a frequently exploited characteristic of lymphoid malignancies. However, in the natural killer (NK) cell subset of large granular lymphocyte proliferations, clonality is difficult to prove because of the lack of specific genetic markers, such as immunoglobulin or T-cell receptor gene rearrangements. The human androgen receptor (HUMARA) assay, a polymerase chain reaction-based X-chromosome inactivation assay, is a potential diagnostic tool in these disorders. Although there is much… CONTINUE READING

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