The human Y chromosome, in the light of evolution

  title={The human Y chromosome, in the light of evolution},
  author={Bruce T. Lahn and Nathaniel M. Pearson and Karin Jegalian},
  journal={Nature Reviews Genetics},
Most eukaryotic chromosomes, akin to messy toolboxes, store jumbles of genes with diverse biological uses. The linkage of a gene to a particular chromosome therefore rarely hints strongly at that gene's function. One striking exception to this pattern of gene distribution is the human Y chromosome. Far from being random and diverse, known human Y-chromosome genes show just a few distinct expression profiles. Their relative functional conformity reflects evolutionary factors inherent to sex… CONTINUE READING

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