The human Y chromosome, in the light of evolution

@article{Lahn2001TheHY,
  title={The human Y chromosome, in the light of evolution},
  author={Bruce T. Lahn and Nathaniel M. Pearson and Karin Jegalian},
  journal={Nature Reviews Genetics},
  year={2001},
  volume={2},
  pages={207-216}
}
Most eukaryotic chromosomes, akin to messy toolboxes, store jumbles of genes with diverse biological uses. The linkage of a gene to a particular chromosome therefore rarely hints strongly at that gene's function. One striking exception to this pattern of gene distribution is the human Y chromosome. Far from being random and diverse, known human Y-chromosome genes show just a few distinct expression profiles. Their relative functional conformity reflects evolutionary factors inherent to sex… CONTINUE READING

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Population genetic implications from sequence variation in four Y chromosome genes.

Proceedings of the National Academy of Sciences of the United States of America • 2000

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