The human V-preB promoter is a target for coordinated activation by early B cell factor and E47.

@article{Gisler2002TheHV,
  title={The human V-preB promoter is a target for coordinated activation by early B cell factor and E47.},
  author={Ramiro Gisler and Mikael Sigvardsson},
  journal={Journal of immunology},
  year={2002},
  volume={168 10},
  pages={5130-8}
}
The development of mature B lymphoid cells involves a highly orchestrated regulation of stage- and lineage-specific genes. In this study, we report an analysis of the human surrogate L chain VpreB promoter. The promoter has an overall homology of 56% to the mouse counterpart and displays a preB cell-restricted activity in transient transfections in cell lines. The promoter harbors three independent binding sites for early B cell factor (EBF) as defined by EMSA and supershift experiments. These… CONTINUE READING
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The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene

  • F. Melchers, E. ten Boekel, T. Yamagami, J. Andersson, A. Rolink
  • loci. Semin. Immunol
  • 1999

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