The human TAZ gene complements mitochondrial dysfunction in the yeast taz1Delta mutant. Implications for Barth syndrome.

@article{Ma2004TheHT,
  title={The human TAZ gene complements mitochondrial dysfunction in the yeast taz1Delta mutant. Implications for Barth syndrome.},
  author={Lining Ma and Fr{\'e}d{\'e}ric M Vaz and Zhiming Gu and Ronald J. A. Wanders and Miriam L Greenberg},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 43},
  pages={44394-9}
}
Barth syndrome is a genetic disorder that is caused by different mutations in the TAZ gene G4.5. The yeast gene TAZ1 is highly homologous to human TAZ, and the taz1Delta mutant has phospholipid defects similar to those observed in Barth syndrome cells, including aberrant cardiolipin species and decreased cardiolipin levels. Subcellular fractionation studies revealed that Taz1p is localized exclusively in mitochondria, which supports the theory that tafazzins are involved in cardiolipin… CONTINUE READING

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