The human T cell receptor: analysis with cytotoxic T cell clones.

@article{Reinherz1983TheHT,
  title={The human T cell receptor: analysis with cytotoxic T cell clones.},
  author={Ellis L. Reinherz and Stefan C. Meuer and Stuart F. Schlossman},
  journal={Immunological reviews},
  year={1983},
  volume={74},
  pages={
          83-112
        }
}
Employing human T lymphocyte clones and monoclonal antibodies to their surface glycoproteins, the antigen receptors on these cells have been defined. Based on functional and biochemical data, it is shown that each T cell displays two major recognition units on its surface. One structure consists of the antigen-binding region (Tin-T3) which views antigen X in the context of a polymorphic region of an MHC molecule. A second (T8 or T4) serves as an associative recognition structure for a constant… CONTINUE READING

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