The human T-cell leukemia virus type-1 Tax protein regulates the activity of the IkappaB kinase complex.

@article{Li1999TheHT,
  title={The human T-cell leukemia virus type-1 Tax protein regulates the activity of the IkappaB kinase complex.},
  author={Xiaohua Li and Kenneth M Murphy and Kevin T Palka and Rama Mohan Surabhi and Richard B. Gaynor},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 48},
  pages={34417-24}
}
Two cytokine-inducible kinases, IKKalpha and IKKbeta, are components of a 700-kDa kinase complex that specifically phosphorylates IkappaB. Phosphorylation of IkappaB by IKK leads to its ubiquitination and subsequent degradation, resulting in the nuclear translocation of NF-kappaB. The oncogenic protein Tax, encoded by human T-cell leukemia virus type-1 (HTLV-1), stimulates IKK activity to result in constitutive nuclear levels of NF-kappaB. In an attempt to gain insights into the mechanism by… CONTINUE READING