The human T-cell cloning assay: identifying genotypes susceptible to drug toxicity and somatic mutation.

  • S M Hou
  • Published 2014 in Methods in molecular biology

Abstract

Humans exhibit marked genetic polymorphisms in drug metabolism that contribute to high incidence of adverse effects in susceptible individuals due to altered balance between metabolic activation and detoxification. The T-cell cloning assay, which detects mutations in the gene for hypoxanthine-guanine phosphoribosyl transferase (HPRT), is the most well… (More)
DOI: 10.1007/978-1-62703-739-6_22

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Cite this paper

@article{Hou2014TheHT, title={The human T-cell cloning assay: identifying genotypes susceptible to drug toxicity and somatic mutation.}, author={S M Hou}, journal={Methods in molecular biology}, year={2014}, volume={1105}, pages={283-9} }