The human SWI/SNF subunit Brm is a regulator of alternative splicing

  title={The human SWI/SNF subunit Brm is a regulator of alternative splicing},
  author={Eric Batsch{\'e} and M. Yaniv and Christian Muchardt},
  journal={Nature Structural &Molecular Biology},
The SWI/SNF (mating-type switch/sucrose nonfermenting) complex involved in chromatin remodeling on promoters has also been detected on the coding region of genes. Here we show that SWI/SNF can function as a regulator of alternative splicing. We found that the catalytic subunit Brm favors inclusion of variant exons in the mRNA of several genes, including E-cadherin, BIM, cyclin D1 and CD44. Consistent with this, Brm associates with several components of the spliceosome and with Sam68, an ERK… CONTINUE READING
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