The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation

  title={The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation},
  author={Eeva-Mari Jouhilahti and Elo Madissoon and Lise Vesterlund and Virpi T{\"o}h{\"o}nen and Kaarel Krjut{\vs}kov and {\'A}lvaro Plaza Reyes and Sophie Petropoulos and Robert Månsson and Sten Linnarsson and Thomas R. B{\"u}rglin and Fredrik Lanner and Outi Hovatta and Shintaro Katayama and Juha Kere},
  journal={Development (Cambridge, England)},
  pages={3459 - 3469}
Leucine twenty homeobox (LEUTX) is a paired (PRD)-like homeobox gene that is expressed almost exclusively in human embryos during preimplantation development. We previously identified a novel transcription start site for the predicted human LEUTX gene based on the transcriptional analysis of human preimplantation embryos. The novel variant encodes a protein with a complete homeodomain. Here, we provide a detailed description of the molecular cloning of the complete homeodomain-containing LEUTX… 

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