The human PIN1 peptidyl-prolyl cis/trans isomerase gene maps to human chromosome 19p13 and the closely related PIN1L gene to 1p31.

@article{Campbell1997TheHP,
  title={The human PIN1 peptidyl-prolyl cis/trans isomerase gene maps to human chromosome 19p13 and the closely related PIN1L gene to 1p31.},
  author={Hugh D. Campbell and Graham C. Webb and Shelley Fountain and Ian G. Young},
  journal={Genomics},
  year={1997},
  volume={44 2},
  pages={
          157-62
        }
}
The human PIN1 gene encodes an essential nuclear peptidyl-prolyl cis/trans isomerase involved in the regulation of mitosis. PIN1 is a member of a new class of peptidyl-prolyl cis/trans isomerases that includes the Escherichia coli parvulin, yeast ESS1, and Drosophila melanogaster dodo gene products. Analysis of human ESTs showed that there are two different but closely related human transcripts, one of which corresponds to PIN1. Gene localization, using both FISH and tritium-labeled probes… Expand
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TLDR
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Comparative analysis of enzyme activities and mRNA levels of peptidyl prolyl cis/trans isomerases in various organs of wild type and Pin1 −/− mice
TLDR
The results show that high PPIase activities of Pin1 are found in organs that have the tendency to develop Pin1 knockout phenotypes and provide the first time an enzymological basis for these observations. Expand
Identification and characterization of a novel and functional murine Pin1 isoform.
TLDR
A novel murine Pin1 isoform (mPin1L) consisting of the WW domain and the PPIase domain is identified, providing insights into phenotypic consequences for Pin1-null mice and may facilitate future biological study and pharmacological development in mice. Expand
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Subsequent treatment with cyclosporin A significantly retarded growth, which suggests that ESS1 and cyclophilin A are functionally linked in yeast cells and play important roles at the G(1) phase of the cell cycle. Expand
Analysis of the interaction of TIP60β and PIN1 with the ets family transcription factor ETV6
TLDR
The ETV6 gene is involved in many chromosomal translocations forming different fusion genes in both myeloid and lymphoid leukemias as well as in some solid tumors, and its interaction with TIP60β and PIN1 is shown to be dependent on an intact acetyltransferase activity of TIP 60β. Expand
The Ess1 prolyl isomerase: traffic cop of the RNA polymerase II transcription cycle.
  • S. Hanes
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 2014
TLDR
Recent work has shown that Ess1 coordinates the binding and release of CTD-binding proteins that function as co-factors in the RNA pol II complex, which plays an integral role in writing (and reading) the so-called CTD code to promote production of mature RNAPol II transcripts including non-coding RNAs and mRNAs. Expand
Solh, the mouse homologue of the Drosophila melanogaster small optic lobes gene: organization, chromosomal mapping, and localization of gene product to the olfactory bulb.
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The antibodies were used to show that the Solh protein localizes to the olfactory bulb in mouse and rat brain, suggesting that it could have an analogous role in development of sensory system neurons in Drosophila and in mammals. Expand
SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia).
TLDR
SOLH is a candidate gene for CATM (hereditary cataracts with microphthalmia), which maps in this region, and northern analysis of human tissues revealed a SOLH transcript of approximately 5 kb that was strongest in human brain. Expand
Pin1: WW domain ligands, catalytic inhibitors, and the mechanism
The peptidyl prolyl cis/trans isomerase, PPIase, has been the focus of numerous studies in the field of cell cycle regulation since proline-directed phosphorylation is an essential signalingExpand
Structure and function of the human parvulins Pin1 and Par14/17
TLDR
This review on human parvulins summarizes the current knowledge of these enzymes and intends to oppose the well-studied Pin1 to its less well-examined homolog human Par14/17 with respect to structure, catalytic and cellular function. Expand
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Pinl is an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity, and is structurally and functionally related to Essl/Ptfl, an essential protein in budding yeast. Expand
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