The human OCT-4 isoforms differ in their ability to confer self-renewal.

@article{Lee2006TheHO,
  title={The human OCT-4 isoforms differ in their ability to confer self-renewal.},
  author={JungWoon Lee and Hye Kyoung Kim and Jeung-yon Rho and Y Han and Jungho Kim},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 44},
  pages={33554-65}
}
OCT-4 transcription factors play an important role in maintaining the pluripotent state of embryonic stem cells and may prevent expression of genes activated during differentiation. Human OCT-4 isoform mRNAs encode proteins that have identical POU DNA binding domains and C-terminal domains but differ in their N-terminal domains. We report here the cloning and characterization of the human OCT-4B isoform. Human OCT-4B cDNA encodes a 265-amino acid protein with a predicted molecular mass of 30… CONTINUE READING

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