The human MT1 melatonin receptor stimulates cAMP production in the human neuroblastoma cell line SH-SY5Y cells via a calcium-calmodulin signal transduction pathway.

Abstract

Melatonin regulates circadian and seasonal physiology via melatonin receptors expressed in the brain. However, little is known about the signal transduction mechanisms that mediate the action of melatonin in neuronal cells. To begin to address this issue, we expressed the human MT(1) receptor in the human neuroblastoma SH-SY5Y cell line. In this cell line… (More)

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@article{Schuster2005TheHM, title={The human MT1 melatonin receptor stimulates cAMP production in the human neuroblastoma cell line SH-SY5Y cells via a calcium-calmodulin signal transduction pathway.}, author={Christoph Schuster and L M Williams and A. Morris and P Jeffrey Morgan and Peter Barrett}, journal={Journal of neuroendocrinology}, year={2005}, volume={17 3}, pages={170-8} }