The human L1 element: a potential biomarker in cancer prognosis, current status and future directions.

@article{Piskareva2011TheHL,
  title={The human L1 element: a potential biomarker in cancer prognosis, current status and future directions.},
  author={Olga Piskareva and William A Lackington and Darragh Lemass and Carol A. Hendrick and P. Doolan and Niall Barron},
  journal={Current molecular medicine},
  year={2011},
  volume={11 4},
  pages={286-303}
}
The discovery of new biomarkers is a rapidly advancing area in cancer biology. The challenge of biomarker development for broad clinical use requires the translation of lab-based knowledge into clinical practice. The Long Interspersed Nuclear Elements-1 (LINE-1s or L1 elements) are active members of an autonomous family of non-LTR retrotransposons and occupy nearly 17% of the human genome. There is strong experimental evidence that the global hypomethylation of genomic DNA in cancer cells… CONTINUE READING

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