The human KB multidrug-resistant cell line KB-C1 is hypersensitive to inhibitors of glycosylation.

@article{Bentley1997TheHK,
  title={The human KB multidrug-resistant cell line KB-C1 is hypersensitive to inhibitors of glycosylation.},
  author={Johanne Bentley and Diana M. Quinn and Richard S. Pitman and J. Roger Warr and George L. Kellett},
  journal={Cancer letters},
  year={1997},
  volume={115 2},
  pages={
          221-7
        }
}
We have previously shown that the hypersensitivity of KB MDR cells to 2-deoxy-D-glucose is associated with diminished plasma membrane GLUT-1 levels compared with parental, non-MDR cells. Here we report that MDR cells are hypersensitive to the N-linked glycosylation inhibitor tunicamycin, which induces partial inhibition of GLUT-1 glycosylation and diminishes GLUT-1-mediated transport. The effect of tunicamycin, which also enhances the hypersensitivity of MDR cells to 2-deoxy-D-glucose, could… CONTINUE READING
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