The human JC polyomavirus (JCPyV): virological background and clinical implications.

  title={The human JC polyomavirus (JCPyV): virological background and clinical implications.},
  author={Hans Hellmuth Hirsch and Piotr Kardas and Denise Kranz and C{\'e}line Leboeuf},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  volume={121 8},
JC polyomavirus (JCPyV) was the first of now 12 PyVs detected in humans, when in 1964, PyV particles were revealed by electron microscopy in progressive multifocal leukoencephalopathy (PML) tissues. JCPyV infection is common in 35-70% of the general population, and the virus thereafter persists in the renourinary tract. One third of healthy adults asymptomatically shed JCPyV at approximately 50,000 copies/mL urine. PML is rare having an incidence of <0.3 per 100,000 person years in the general… CONTINUE READING
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