The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.

@article{Borkhardt2000TheHG,
  title={The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.},
  author={Arndt Borkhardt and Sophie Bojesen and Oskar Arthur Haas and Uta E Fuchs and D Bartelheimer and Ivan F. Loncarevic and Rainer Bohle and Jochen Harbott and Reinald Repp and Ulrich Jaeger and Susanne F Viehmann and T. Henn and Prof. Dr. J. Korth and D Scharr and Fritz Lampert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 16},
  pages={9168-73}
}
We have isolated the human GRAF gene (for GTPase regulator associated with the focal adhesion kinase pp125(FAK)). This gene was fused with MLL in a unique t(5;11)(q31;q23) that occurred in an infant with juvenile myelomonocytic leukemia. GRAF encodes a member of the Rho family of the GTPase-activating protein (GAP) family. On the protein level, it is 90% homologous to the recently described chicken GRAF gene that functions as a GAP of RhoA in vivo and is thus a critical component of the… CONTINUE READING

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