The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins.

@article{Hayward1998TheHG,
  title={The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins.},
  author={Bruce E. Hayward and Megumi Kamiya and Lisa Strain and Ver{\'o}nica Mor{\'a}n and Roderick B. Campbell and Yoshihide Hayashizaki and David T. Bonthron},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 17},
  pages={10038-43}
}
The GNAS1 gene encodes the alpha subunit of the G protein Gs, which couples receptor binding by several hormones to activation of adenylate cyclase. Null mutations of GNAS1 cause pseudohypoparathyroidism (PHP) type Ia, in which hormone resistance occurs in association with a characteristic osteodystrophy. The observation that PHP Ia almost always is inherited maternally has led to the suggestion that GNAS1 may be an imprinted gene. Here, we show that, although Gsalpha expression (directed by… CONTINUE READING
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