The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion

@article{Brakenhoff1995TheHE,
  title={The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion},
  author={Ruud H. Brakenhoff and Martijn Gerretsen and E M Knippels and Marie van Dijk and Heinz-Hermann Essen and Danielle Olde Weghuis and Richard J Sinke and Gordon B J Snow and G. A. M. S. van Dongen},
  journal={The Journal of Cell Biology},
  year={1995},
  volume={129},
  pages={1677 - 1689}
}
The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man. To anticipate the effect of high antibody dose treatment, and to evaluate the possible biological involvement of the antigen in carcinogenesis, we set out to molecularly characterize the antigen. A cDNA clone encoding the E48 antigen was isolated… CONTINUE READING

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