The human Cx40 promoter polymorphism -44G-->A differentially affects transcriptional regulation by Sp1 and GATA4.

@article{Firouzi2006TheHC,
  title={The human Cx40 promoter polymorphism -44G-->A differentially affects transcriptional regulation by Sp1 and GATA4.},
  author={Mehran Firouzi and Marti F. A. Bierhuizen and Bart G. J. M. Kok and Birgit E J Teunissen and Anita T. M. Jansen and Habo J. Jongsma and W Antoinette Groenewegen},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1759 10},
  pages={491-6}
}
Expression of the tissue-specific gap junction protein connexin(Cx)40 is regulated by the interaction of ubiquitous and tissue-specific factors such as Sp1 and GATA4. Cardiac Cx40 expression is altered under pathological conditions such as atrial fibrillation. A human promoter polymorphism, a G-->A change at position -44 that has been associated with atrial-specific arrhythmias, is located between the TBE-NKE-Sp and GATA consensus transcription factor binding sites important for the regulation… CONTINUE READING

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