The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys.

@article{Brok2007TheHC,
  title={The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys.},
  author={Herbert P. M. Brok and Leonie A. Boven and Marjan van Meurs and Nicole Kerlero de Rosbo and Liesbeth Celebi-Paul and Yolanda S Kap and Anwar Jagessar and Rogier Q. Hintzen and Geoffrey Keir and Jeffrey J Bajramovic and Avraham Ben-Nun and Jan Niklas Bauer and Jon D Laman and Sandra Amor and Bert A 't Hart},
  journal={Journal of neuroimmunology},
  year={2007},
  volume={182 1-2},
  pages={135-52}
}
Rhesus monkeys immunized with MOG(34-56), a dominant T-cell epitope from myelin/oligodendrocyte glycoprotein, develop an acute neurological disease resembling acute disseminated encephalomyelitis (ADEM) in humans. The typical large demyelinated lesions and mononuclear infiltrates in the monkey brains are caused by MOG(34-56) T-cells. We show that MOG(34-56)-reactive CD4+ and CD8+ T-cells are induced in monkeys immunized with a peptide from the human CMV major capsid protein (UL86; 981-1003… CONTINUE READING