The human CK gene segment and the kappa deleting element are closely linked.

@article{Klobeck1986TheHC,
  title={The human CK gene segment and the kappa deleting element are closely linked.},
  author={H. G. Klobeck and H. G. Zachau},
  journal={Nucleic acids research},
  year={1986},
  volume={14 11},
  pages={4591-603}
}
The element which mediates the deletion of the CK gene segment (abbreviations ref. 1) in human lambda light chain producing B-cells was found to be located 24 kb downstream of CK. The kappa deleting element is flanked by hepta- and nonanucleotide recognition sequences similar to the ones adjacent to the JK gene segments. Complementary recognition sequences with a 30 bp spacer were found in the JK-CK intron. For the first time the two partners of a recombination event in a mammalian… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
17 Citations
14 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 14 references

Ann. Rev. Biochem. Nucleic Acids Research

  • T Honjo, S Habu
  • Ann. Rev. Biochem. Nucleic Acids Research
  • 1985

Mol. Cell. Biol

  • C T Denny, G F Hollis, I T Magrath, I R Kirsch
  • Mol. Cell. Biol
  • 1985

Nucl. Acids Res

  • H G Klobeck, G W Bornkamm, G Combriato, R Mocikat, H D Pohlenz, H G Zachau
  • Nucl. Acids Res
  • 1985

Proc. Natl. Acad. Scl. USA 82

  • M W Moore, J Durdik, D M Persiani, E Seising
  • Proc. Natl. Acad. Scl. USA 82
  • 1985

Gene

  • J Norrander, T Kempe, J Messing
  • Gene
  • 1983

J. Mol. Biol

  • A M Frischauf, H Lehrach, A Poustka, N Murray
  • J. Mol. Biol
  • 1983

Nature

  • S Tonegawa
  • Nature
  • 1983

J. Exp. Med

  • S J Korsmeyer, P A Hieter, S A Sharrow, C K Goldman, P Leder, T A Waldmann
  • J. Exp. Med
  • 1982

Proc. Natl. Acad. Sci. USA 79

  • Van Ness, B G Coleclough, C Perry, R P Weigert
  • Proc. Natl. Acad. Sci. USA 79
  • 1982

Cell

  • P A Hieter, E E Max, J G Seidman, J V Maizel, P Leder
  • Cell
  • 1980

Similar Papers

Loading similar papers…