The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants.

@article{Imamura2003TheHB,
  title={The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants.},
  author={Osamu Imamura and Judith L. Campbell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 14},
  pages={8193-8}
}
Bloom syndrome is a disorder of profound and early cancer predisposition in which cells become hypermutable, exhibit high frequency of sister chromatid exchanges, and show increased micronuclei. BLM, the gene mutated in Bloom syndrome, has been cloned previously, and the BLM protein is a member of the RecQ family of DNA helicases. Many lines of evidence suggest that BLM is involved either directly in DNA replication or in surveillance during DNA replication, but its specific roles remain… CONTINUE READING