The human B lymphocyte and carcinoma antigen, CDw40, is a phosphoprotein involved in growth signal transduction.

@article{Paulie1989TheHB,
  title={The human B lymphocyte and carcinoma antigen, CDw40, is a phosphoprotein involved in growth signal transduction.},
  author={Staffan Paulie and Antony Rosen and Barbro Ehlin-Henriksson and Sten Braesch-Andersen and Eva Jakobson and Hannu Koho and Peter Perlmann},
  journal={Journal of immunology},
  year={1989},
  volume={142 2},
  pages={590-5}
}
The human B lymphocyte and carcinoma-associated Ag, CDw40, (p50, Bp50) is a receptor candidate for normal growth regulation. Interaction of mAb with this pan-B Ag, together with preactivating agents such as 12-O-tetradecanoylphorbol-13-acetate or anti-mu, deliver strong growth-promoting signals to the cells. We here demonstrate that signaling through this Ag is dependent on its aggregation on the cell surface. Thus, monovalent antibody fragments were relatively inefficient in this respect but… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…