The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing.

@article{Ochiana2013TheHA,
  title={The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing.},
  author={Stefan O. Ochiana and Vidya Pandarinath and Zhouxi Wang and Rishika Kapoor and Mary Jo Ondrechen and Larry Ruben and Michael P Pollastri},
  journal={European journal of medicinal chemistry},
  year={2013},
  volume={62},
  pages={
          777-84
        }
}
New drugs for neglected tropical diseases such as human African trypanosomiasis (HAT) are needed, yet drug discovery efforts are not often focused on this area due to cost. Target repurposing, achieved by the matching of essential parasite enzymes to those human enzymes that have been successfully inhibited by small molecule drugs, provides an attractive means by which new drug optimization programs can be pragmatically initiated. In this report we describe our results in repurposing an… CONTINUE READING
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