The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population.

@article{Terao2011TheHA,
  title={The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population.},
  author={Chikashi Terao and Ryo Yamada and Koichiro Ohmura and Meiko Takahashi and Takahisa Kawaguchi and Yuta Kochi and Yukinori Okada and Yusuke Nakamura and Kazuhiko Yamamoto and Inga Melchers and Mark Lathrop and Tsuneyo Mimori and Fumihiko Matsuda},
  journal={Human molecular genetics},
  year={2011},
  volume={20 13},
  pages={2680-5}
}
Rheumatoid arthritis (RA) is a typical complex trait and the major cause of chronic inflammation worldwide. Although multiple genetic loci have been shown for their association with the onset of RA, they cover only a part of its genetic components and are largely ethnicity-specific. To identify novel genetic factors related to the predisposition and prognosis of RA in Japanese, we conducted a large-scale genome-wide association (GWA) study. We performed a GWA analysis by scanning the genome of… CONTINUE READING

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