The hotspot conversion paradox and the evolution of meiotic recombination.

  title={The hotspot conversion paradox and the evolution of meiotic recombination.},
  author={A. Boulton and Richard S Myers and Rosemary J. Redfield},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 15},
Studies of meiotic recombination have revealed an evolutionary paradox. Molecular and genetic analysis has shown that crossing over initiates at specific sites called hotspots, by a recombinational-repair mechanism in which the initiating hotspot is replaced by a copy of its homolog. We have used computer simulations of large populations to show that this mechanism causes active hotspot alleles to be rapidly replaced by inactive alleles, which arise by rare mutation and increase by… CONTINUE READING
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Boulton et al

  • A. Datta, Jinks-Robertson, S. Science 268, 1616–1619. Genetics
  • Proc. Natl. Acad. Sci. USA 94
  • 1997

An Introduction to Genetic Analysis (Freeman

  • A. J. Griffiths, J. H. Miller, D. T. Suzuki, R. C. Lewontin, W. M. Gelbart
  • 1996

Principles of Population Genetics (Sinauer

  • D. L. Hartl, A. G. Clark
  • 1989

Mechanisms in Recombination, ed

  • R. K. Mortimer, S. Fogel
  • 1974

Mathematical Topics in Population Genetics, ed

  • J. F. Crow
  • 1970

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