The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice.

@article{Boyartchuk2004TheHR,
  title={The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice.},
  author={Victor Boyartchuk and M. Diaz de Rojas and B Yan and Ousman Jobe and Nicholas Hurt and David M Dorfman and Darren E. Higgins and William F. Dietrich and Igor Kramnik},
  journal={Journal of immunology},
  year={2004},
  volume={173 8},
  pages={5112-20}
}
Epidemiological, clinical, and experimental approaches have convincingly demonstrated that host resistance to infection with intracellular pathogens is significantly influenced by genetic polymorphisms. Using a mouse model of infection with virulent Mycobacterium tuberculosis (MTB), we have previously identified the sst1 locus as a genetic determinant of host resistance to tuberculosis. In this study we demonstrate that susceptibility to another intracellular pathogen, Listeria monocytogenes… CONTINUE READING
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