The host environment is responsible for aging-related functional NK cell deficiency.

@article{Chiu2013TheHE,
  title={The host environment is responsible for aging-related functional NK cell deficiency.},
  author={Bo-chin Chiu and Brian K. Martin and Valerie R Stolberg and Stephen W. Chensue},
  journal={Journal of immunology},
  year={2013},
  volume={191 9},
  pages={4688-98}
}
NK cells play an important role in immunity against infection and tumors. Aging-related functional NK cell deficiency is well documented in humans and mice. However, the mechanism for this is poorly understood. Using an adoptive transfer approach in mice, we found that NK cells from both young and aged mice responded vigorously to priming by pathogen-derived products after being cotransferred into young mice. In contrast, NK cells from young mice responded poorly to priming by pathogen-derived… CONTINUE READING
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