The host defense peptide LL-37 selectively permeabilizes apoptotic leukocytes.


LL-37 is a cationic host defense peptide that is highly expressed during acute inflammation and that kills bacteria by poorly defined mechanisms, resulting in permeabilization of microbial membranes. High concentrations of LL-37 have also been reported to have cytotoxic effects against eukaryotic cells, but the peptide is clearly capable of differentiating… (More)
DOI: 10.1128/AAC.01310-08


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