The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance.

@article{Pihlajamki2001TheHS,
  title={The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance.},
  author={Jussi Pihlajam{\"a}ki and Raisa Valve and Leena Karjalainen and Pauli Karhap{\"a}{\"a} and Ilkka Vauhkonen and Markku Laakso},
  journal={European journal of clinical investigation},
  year={2001},
  volume={31 4},
  pages={
          302-8
        }
}
BACKGROUND Insulin resistance in the most common familial dyslipidemia, familial combined hyperlipidemia (FCHL), could be due to variations in the hormone sensitive lipase (HSL) gene. MATERIALS AND METHODS The coding region of the HSL gene was screened with the single strand conformation polymorphism analysis in probands of 27 FCHL families with 228 members. In addition, the C-60G promoter substitution of the HSL gene was determined by the restriction fragment length polymorphism analysis in… CONTINUE READING
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