The hormone resistin links obesity to diabetes
@article{Steppan2001TheHR, title={The hormone resistin links obesity to diabetes}, author={C. Steppan and S. Bailey and S. Bhat and E. Brown and R. Banerjee and C. Wright and H. R. Patel and R. Ahima and M. Lazar}, journal={Nature}, year={2001}, volume={409}, pages={307-312} }
Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance… Expand
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