The hormone resistin links obesity to diabetes

  title={The hormone resistin links obesity to diabetes},
  author={Claire M. Steppan and Shannon T. Bailey and Savitha Bhat and Elizabeth J. Brown and Ronadip R. Banerjee and Christopher M Wright and Hiralben R Patel and Rexford S. Ahima and Mitchell A. Lazar},
Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance… 
Linking resistin, inflammation, and cardiometabolic diseases
The role of human resistin in the pathogeneses of inflammation and obesity-related diseases is focused on and recent evidence suggests that resistin is associated with atherogenic dyslipidemia and hypertension.
Resistin in Rodents and Humans
Obesity is characterized by excess accumulation of lipids in adipose tissue and other organs, and chronic inflammation associated with insulin resistance and an increased risk of type 2 diabetes.
Resistin and obesity-associated insulin resistance
Insulin resistance as the core defect in type 2 diabetes mellitus.
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The current biology of resistin
This review will summarize the current understanding of resistin and will attempt to provide a framework for future study of its role in rodent and human physiology.
Insulin Resistance and Insulin Sensitizers
Fine-mapping and positional cloning of the susceptibility locus on chromosome 2 resulted in the identification of a polymorphism (UCSNP-43 G/A) in the calpain-10 gene, and in non-diabetic Pima Indians, this polymorphism was associated with insulin resistance of glucose disposal.
Implications of resistin in type 2 diabetes mellitus and coronary artery disease: Impairing insulin function and inducing pro‐inflammatory cytokines
The effects of resistin on inflammation and insulin resistance that may lead to type 2 diabetes and CAD are explored.
Role of Resistin in Inflammation, Obesity and Type2 Diabetes mellitus
This review will place available data on resistin in the context of the current knowledge of the pathogenesis of obesity)mediated diabetes.
Associations of resistin with inflammation and insulin resistance in patients with type 2 diabetes mellitus
Resistin showed significant BMI‐dependent associations with insulin resistance and factors linked with obesity and inflammation in patients with type 2 diabetes and may represent a link between obesity and insulin resistance via pro‐inflammatory pathways.
Molecular mechanisms of insulin resistance and associated diseases.


Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
It is shown that insulin resistance in lipodystrophic mice can be overcome by a continuous systemic infusion of low doses of recombinant leptin, an effect that is not mimicked by chronic food restriction.
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Continuously elevated levels of plasma FFAs may play a key role in the pathogenesis of NIDDM in predisposed individuals by impairing peripheral glucose utilization and by promoting hepatic glucose overproduction.
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    Trends in Endocrinology & Metabolism
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These findings represent the first germline loss-of-function mutations in PPARγ and provide compelling genetic evidence that this receptor is important in the control of insulin sensitivity, glucose homeostasis and blood pressure in man.
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It is proposed that regulation of the neuroendocrine system during starvation could be the main physiological role of leptin, and preventing the starvation-induced fall in leptin with exogenous leptin substantially blunts the changes in gonadal, adrenal and thyroid axes in male mice, and prevents the starve-induced delay in ovulation in female mice.
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