• DOI:10.1038/35053000
Corpus ID: 4358808

The hormone resistin links obesity to diabetes

@article{Steppan2001TheHR,
  title={The hormone resistin links obesity to diabetes},
  author={C. Steppan and S. Bailey and S. Bhat and E. Brown and R. Banerjee and C. Wright and H. R. Patel and R. Ahima and M. Lazar},
  journal={Nature},
  year={2001},
  volume={409},
  pages={307-312}
}

• C. Steppan, S. Bailey, +6 authors M. Lazar
• Published 2001
• Biology, Medicine
• Nature

Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance… Expand

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