The homozygous P582S mutation in the oxygen-dependent degradation domain of HIF-1 alpha is associated with increased risk for prostate cancer.

@article{OrrUrtreger2007TheHP,
  title={The homozygous P582S mutation in the oxygen-dependent degradation domain of HIF-1 alpha is associated with increased risk for prostate cancer.},
  author={Avi Orr-Urtreger and Anat Bar-Shira and Haim Matzkin and Nicola J Mabjeesh},
  journal={The Prostate},
  year={2007},
  volume={67 1},
  pages={
          8-13
        }
}
BACKGROUND The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor 1), consisting of a critically regulated HIF-1 alpha subunit and a constitutively expressed HIF-1 beta subunit, is a master regulator of genes involved in adaptation and survival under low-oxygen conditions. Increased levels of HIF-1 activity are associated with increased tumor aggressiveness, therapeutic resistance, and mortality. METHODS We studied 402 prostate cancer patients for the presence of the 1772C > T… CONTINUE READING

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