The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo

@article{Weigel1989TheHG,
  title={The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo},
  author={Detlef Weigel and Gerd J{\"u}rgens and Frank K{\"u}ttner and Eveline Seifert and Herbert Jäckle},
  journal={Cell},
  year={1989},
  volume={57},
  pages={645-658}
}

Figures from this paper

Primordium specific requirement of the homeotic gene fork head in the developing gut of the Drosophila embryo

TLDR
Molecular analysis revealed that fkh expression is not restricted to the ectodermal parts of the gut, but is detectable in a variety of other tissues, and the phenotype of fkh mutant embryos was re-examined using molecular probes as tissue specific markers.

The Drosophila fork head domain protein crocodile is required for the establishment of head structures.

TLDR
The croc mutant phenotype indicates that the croc wild‐type gene is required to function as an early patterning gene in the anterior‐most blastoderm head segment anlage and for the establishment of a specific head skeletal structure that derives from the non‐adjacent intercalary segment at a later stage of embryogenesis.

The Drosophila trithorax gene encodes a chromosomal protein and directly regulates the region-specific homeotic gene fork head.

TLDR
Results show that trithorax maintains expression of target genes by interaction with their regulatory regions and that this interaction depends on the presence of at least some of the other trathorax and Polycomb group proteins.

Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity.

TLDR
It is found that the N terminus of the homeodomain is critical for determining the specific effects of these homeotic proteins in vivo, but other parts of the proteins have some influence as well.

bowel, an odd‐skipped homolog, functions in the terminal pathway during Drosophila embryogenesis.

TLDR
The results indicate that the developmental roles of odd‐skipped and bowel have diverged substantially, and that bowel represents a new member of the terminal hierarchy that acts downstream of tailless and mediates a subset of tailledess functions in the posterior of the embryo.

A Drosophila Winged‐helix nude (Whn)‐like transcription factor with essential functions throughout development

TLDR
Dwhn is the first invertebrate Whn‐like transcriptional regulator, and should provide insights into the basic functions and evolution of the whn family genes.

PES-1 is expressed during early embryogenesis in Caenorhabditis elegans and has homology to the fork head family of transcription factors.

TLDR
Analysis of cDNA suggests pes-1 has two sites for initiation of transcription and the two transcripts would encode related but distinct proteins, which have homology to the fork head family of transcription factors and therefore may have important regulatory roles in early embryogenesis.

The mouse homolog of the orphan nuclear receptor tailless is expressed in the developing forebrain.

TLDR
A mouse homolog of the Drosophila tailless gene is isolated, which shows considerable homology in the DNA-binding domain suggesting that the respective proteins bind similar recognition sequences.

Structural characterization of the mouse Hfh4 gene, a developmentally regulated forkhead family member.

TLDR
Transfection of plasmids containing Hfh4 5' flanking sequence linked to a reporter gene results in promoter activity in lung epithelial cells but not in epithelial-like fibrosarcoma cells, suggesting that this 5'Flanking sequence can function as a promoter with the proper cell-type specificity.
...

References

SHOWING 1-10 OF 67 REFERENCES

Divergent homeo box proteins recognize similar DNA sequences in Drosophila

A member of a small group of genes in Drosophila that define the segmentation pattern of the early embryo1–5 even-skipped (eve), which plays a key role in a network of interactions among segmentation

The sequence specificity of homeodomain-DNA interaction

EGF homologous sequences encoded in the genome of Drosophila melanogaster, and their relation to neurogenic genes.

TLDR
Screening genomic and cDNA libraries under conditions of reduced stringency with Dl and N probes that encode EGF‐like repeats uncovered several cross‐hybridizing clones, suggesting that other Drosophila genes may also encode such peptides.

Head and tail development of the Drosophila embryo involves spalt, a novel homeotic gene

TLDR
It is proposed that the region‐specific action of the sal gene primarily promotes head as opposed to trunk development, while the BX‐C gene AbdB distinguishes tail from head.

Graded requirement for the zygotic terminal gene, tailless, in the brain and tail region of the Drosophila embryo.

TLDR
It is proposed that tll establishes anterior and posterior subdomains within the larger pattern regions affected by the maternal terminal genes, and is placed within the hierarchy of maternal and zygotic genes required for the formation of the normal body pattern.

Pair-rule segmentation genes regulate the expression of the homeotic selector gene, Deformed

TLDR
The results support the idea that a hierarchy of homeobox regulatory genes plays a key role in dividing and determining the Drosophila body pattern.

Expression, modification, and localization of the fushi tarazu protein in Drosophila embryos.

TLDR
An ftz overexpression system functional in Drosophila was developed and it was found that when fused to an hsp70 heat shock promoter and introduced into the germ line by P-element-mediated transformation, ftz could be overexpressed at all stages of development by heat shock.

The white gene as a marker in a new P-element vector for gene transfer in Drosophila.

We describe new vectors suitable for P-element mediated germ line transformation of Drosophila melanogaster using passenger genes whose expression does not result in a readily detectable phenotypic
...