The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons.

@article{Chung2005TheHT,
  title={The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons.},
  author={Sangmi Chung and Eva Hedlund and Michelle E Hwang and Dae Won Kim and B-S Shin and D-Y Hwang and Un Jung Kang and O. Isacson and Kwang-Soo Kim},
  journal={Molecular and cellular neurosciences},
  year={2005},
  volume={28 2},
  pages={241-52}
}
The A9 dopaminergic (DA) neuronal group projecting to the dorsal striatum is the most vulnerable in Parkinson's disease (PD). We genetically engineered mouse embryonic stem (ES) cells to express the transcription factors Nurr1 or Pitx3. After in vitro differentiation of Pitx3-expressing ES cells, the proportion of DA neurons expressing aldehyde dehydrogenase 2 (AHD2) increased, while the total number of DA neurons remained the same. The highest levels of AHD2 expression were observed in mouse… CONTINUE READING
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