The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.

@article{Ohneda2000TheHO,
  title={The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.},
  author={Kinuko Ohneda and Raghavendra G Mirmira and Jun Wang and Joyce D Johnson and Michael S. German},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 3},
  pages={900-11}
}
Activation of insulin gene transcription specifically in the pancreatic beta cells depends on multiple nuclear proteins that interact with each other and with sequences on the insulin gene promoter to build a transcriptional activation complex. The homeodomain protein PDX-1 exemplifies such interactions by binding to the A3/4 region of the rat insulin I promoter and activating insulin gene transcription by cooperating with the basic-helix-loop-helix (bHLH) protein E47/Pan1, which binds to the… CONTINUE READING
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