The homeobox gene Distal-less induces ventral appendage development in Drosophila.

  title={The homeobox gene Distal-less induces ventral appendage development in Drosophila.},
  author={Nicole Gorfinkiel and Gin{\'e}s Morata and Ivonne Guerrero},
  journal={Genes & development},
  volume={11 17},
This study investigates the role of the homeobox gene Distal-less (Dll) in the development of the legs, antennae, and wings of Drosophila. Lack of Dll function causes a change in the identity of ventral appendage cells (legs and antennae) that often results in the loss of the appendage. Ectopic Dll expression in the proximal region of ventral appendages induces nonautonomous duplication of legs and antennae by the activation of wingless and decapentaplegic. Ectopic Dll expression in dorsal… CONTINUE READING
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