The homeobox gene Cdx1 belongs to the p53-p21(WAF)-Bcl-2 network in intestinal epithelial cells.

@article{Moucadel2002TheHG,
  title={The homeobox gene Cdx1 belongs to the p53-p21(WAF)-Bcl-2 network in intestinal epithelial cells.},
  author={Virginie Moucadel and Maria Serena Totaro and Claire Domon Dell and Philippe Soubeyran and Jean Charles Dagorn and Jean Noel Freund and Juan Iovanna},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={297 3},
  pages={607-15}
}
Because the Cdx1 homeobox gene stimulates proliferation and induces transformation and tumorigenesis, it has been investigated whether it is involved in the complex network comprising p53, p21(WAF), and Bcl-2 in intestinal epithelial cells. Non-transformed intestinal IEC-6 cells and colon adenocarcinoma SW480 cells were used to study the putative molecular relationship between Cdx1, p53, p21(WAF), and Bcl-2. Wild-type p53 inhibited the transcriptional activity of the Cdx1 promoter whereas the… CONTINUE READING