The hitchhiker’s guide to the voltage-gated sodium channel galaxy

@inproceedings{Ahern2016TheHG,
  title={The hitchhiker’s guide to the voltage-gated sodium channel galaxy},
  author={Christopher A. Ahern and Jian Payandeh and Frank Bosmans and Baron Chanda},
  booktitle={The Journal of general physiology},
  year={2016}
}
Eukaryotic voltage-gated sodium (Nav) channels contribute to the rising phase of action potentials and served as an early muse for biophysicists laying the foundation for our current understanding of electrical signaling. Given their central role in electrical excitability, it is not surprising that (a) inherited mutations in genes encoding for Nav channels and their accessory subunits have been linked to excitability disorders in brain, muscle, and heart; and (b) Nav channels are targeted by… CONTINUE READING