The histotoxicity of cyanoacrylates

  title={The histotoxicity of cyanoacrylates},
  author={Harry V. Vinters and Khadry A. Galil and Mark J. Lundie and John C. E. Kaufmann},
SummaryCyanoacrylates, a group of rapidly polymerizing adhesives, have found widespread uses in oral and general surgery as well as surgical subspecialties, for example as hemostatic and anastomotic agents. They have been utilized most recently as materials for embolotherapy of complex cerebral and extra-cerebral vascular anomalies. The histopathology that results from their deposition in human tissues is thus an important consideration, and the subject of this review. Particular attention is… 
Tissue Response to N-butyl-2-cyanoacrylate After Percutaneous Injection Into Cutaneous Vascular Lesions
The authors report the consecutive pathological findings of a patient who underwent surgery for facial hemangioma after percutaneous injection of NBCA for devascularization of a lesion, and underwent additional surgery 1 and 6 months after the initial operation for the removal of the residual NBCA cast from the injection site.
The Use of Isobutylcyanoacrylate as a Tissue Adhesive in Abdominal Surgery
Isobutyl-2-cyanoacrylate proved to be a very effective tissue adhesive for both solid and hollow organs, even for high risk surgical operations.
Nonthermal Ablation of Saphenous Reflux
  • S. Elias
  • Medicine
    Atlas of Endovascular Venous Surgery
  • 2019
Cyanoacrylate Adhesive for the Closure of Truncal Veins
Injection of CA is feasible for closure of superficial veins in animal models and results were consistent with a chronic foreign-body-type inflammatory response.
The use of cyanoacrylate tissue adhesive in high-risk intestinal anastomoses
No experimental or clinical studies have shown that this glue has any carcinogenic or mutagenic properties, and it is believed that n-butyl-2-cyanoacrylate will be extremely useful for intestinal anastomoses with a high risk of dehiscence.
Endovascular Use of Cyanoacrylate-Lipiodol Mixture for Peripheral Embolization: Properties, Techniques, Pitfalls, and Applications
The characteristics, properties, mechanisms of action, modalities of use, and indications of the cyanoacrylate-Lipiodol® combination for peripheral embolization are described.
Non-thermal endovenous treatment: acrylat adhesion of varicose saphenous veins
The present work analyses the current state of knowledge on the latest to be developed, cyanoacrylate adhesion of incompetent saphenous veins and concludes that non-thermal procedures which do not require the use of tumescent anaesthesia are coming onto the market.
Polymeric materials for embolic and chemoembolic applications.
In vivo study of ethyl-2-cyanoacrylate applied in direct contact with nerves regenerating in a novel nerve-guide
Stitch suture is still the most recommended method to hold a nerve-guide in place but stitch suture is a well known cause of local inflammatory response. Glues of several kinds have been proposed as


Pathology of arteriovenous malformations embolized with isobutyl-2-cyanoacrylate (bucrylate). Report of two cases.
There is controversy as to the possible toxic effects of isobutyl-2-cyanoacrylate (bucrylate) when this substance is used for purposes of therapeutic embolization. Two cases are presented in which
Toxicity of alkyl 2-cyanoacrylates. I. Peripheral nerve.
THE USE of a tissue adhesive for surgical procedures has long been an appealing possibility. The development of such an adhesive in the form of methyl 2-cyanoacrylate monomer has prompted a large
Higher homologous cyanoacrylate tissue adhesives in surgery of internal organs.
It is believed that the success of surgical application of the cyanoacrylate tissue adhesive is dependent on the new surgical techniques suitable for the use of monomers in addition to development of a better monomer(s).
Histoacryl (butyl cyanoacrylate) as an ossicular adhesive
Not only were they toxic to the tissues, causing middle and inner ear damage, but they also failed to achieve satisfactory functional union between the ossicles, so it was felt that, in tympanoplastic surgery, better hearing results were more likely to come from improved operative technique rather than improved adhesives.
Toxicity of alkyl 2-cyanoacrylates. II. Bacterial growth.
A family of adhesives, the alkyl 2-cyanoacrylates, have been receiving increasing attention from surgeons in the hope of improving various surgical procedures, and interest evolved by the introduction of the methyl monomer.
Intravascular use of isobutyl 2-cyanoacrylate: Part 1 Treatment of intracranial arteriovenous malformations.
The intravascular use of the rapidly polymerizing acrylic compound, isobutyl 2-cyanoacrylate (IBC), in 10 patients with intracranial arteriovenous malformations (AVMs) is described and there was no operative mortality nor permanent neurological morbidity.
Transcatheter occlusive therapy of genitourinary abnormalities using isobutyl 2-cyanoacrylate (Bucrylate).
Transcatheter occlusive therapy was performed with isobutyl 2-cyanoacrylate (Bucrylate) in 14 patients with a variety of genitourinary abnormalities and was used without complications or evidence of histotoxicity.
Cyanoacrylate Tissue Adhesives
Experimental observations demonstrated a dichotomy among the alkyl-2-cyanoacrylates in regard to local toxicity, and showed that the methyl homologue was logically toxic whereas the hexyl and decyl homologues were not.
Staining procedure to aid in assessment of bucrylate histotoxicity in tissue sections.
This work outlines a staining procedure that demonstrates bucrylate in tissue sections and suggests this stain may be effectively utilized to assess harmful tissue reactions to buCrylate.
Neural and vascular tissue reaction to aneurysm-coating adhesive (ethyl 2-cyanoacrylate).
The effect of ethyl 2-cyanoacrylate (Aaron-2-Alpha) obtained from two different manufactures was evaluated in 37 cats divided into two groups and revealed marked neurological deficits when adhesives are applied in critical areas.